LOX-1 deletion alters signals of myocardial remodeling immediately after ischemia–reperfusion
نویسندگان
چکیده
منابع مشابه
LOX-1 deletion alters signals of myocardial remodeling immediately after ischemia-reperfusion.
OBJECTIVE Chronic ischemia is associated with alterations in genes that result in myocardial remodeling. An important biochemical basis of cardiac remodeling is generation of reactive oxygen species (ROS). A few studies have suggested that acute ischemia triggers signals for remodeling. We examined the hypothesis that targeted deletion of lectin-like oxidized-LDL receptor (LOX-1) may inhibit si...
متن کاملConfirmation of LOX-1 Deletion LOX-1 Deletion and Fibroblast Proliferation
Heart failure resulting from cardiac remodeling is the leading cause of morbidity and mortality in the United States and is becoming a major problem worldwide. The remodeling process is defined as progressive increase in ventricular wall volume and myocardial mass. The increase in cardiac mass comes from hypertrophy of cardiomyocytes and proliferation of cardiac fibroblasts, resulting in collag...
متن کاملMyocardial remodeling after discrete radiofrequency injury: effects of tissue inhibitor of matrix metalloproteinase-1 gene deletion.
Discrete myocardial lesions created through the delivery of radiofrequency (RF) energy can expand; however, the mechanisms have not been established. Matrix metalloproteinases (MMPs) play an important role in myocardial remodeling, and MMP activity can be regulated by the tissue inhibitors of the metalloproteinases (TIMPs). This study examined the role of TIMP-1 in postinjury myocardial remodel...
متن کاملMicrosomal prostaglandin E2 synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction.
BACKGROUND Pharmacological inhibition of cyclooxygenase-2 increases the risk of myocardial infarction (MI) and stroke. Microsomal prostaglandin (PG) E(2) synthase-1 (mPGES-1), encoded by the Ptges gene, functions downstream from cyclooxygenase-2 in the inducible PGE(2) biosynthetic pathway. We caused acute MI in Ptges(+/+) and Ptges(-/-) mice to define the role of mPGES-1 in cardiac ischemic in...
متن کاملAnti-streptokinase Antibody Detection before and Immediately after Streptokinase Therapy in Patients with Myocardial Infarction
Background: Myocardial infarction (MI) is one of the most common and serious diseases resulting from coronary artery occlusion and major reduction in blood flow. Streptokinase as a thrombolytic is considered the first and most important therapeutic intervention for reperfusion following MI in most countries including Iran. Our previous study showed that, the prevalence of high antibody titers a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2007
ISSN: 0008-6363
DOI: 10.1016/j.cardiores.2007.07.003